Unsaturated iron-binding capacity: a screening test for C282Y hemochromatosis?

نویسندگان

  • P C Adams
  • V Bhayana
چکیده

with “BD SST 1 double centrifugation” (P ,0.0001, paired t-test). Deming regression analysis yielded the following: slope 5 1.16 [95% confidence interval (95% CI), 1.03–1.29]; intercept 5 0.04 mg/L (95% CI, 0.02– 0.06 mg/L). Table 1 shows the assay values of the six apparently falsepositive results. These results prompted a second phase, during which the BD Thrombin sample was also centrifuged twice. Nineteen additional patients were included. The difference between the results (cTnI range, 0.01–24 mg/L, 32% above threshold) was not statistically significant as analyzed by the paired t-test and the Deming regression [slope 5 1.04 (95% CI, 0.93–1.14); intercept 5 20.03 mg/L (95% CI, 20.08 to 0.02 mg/L)]. We conclude that a single centrifugation of collection tubes containing thrombin as a clot activator is insufficient to avoid false-positive cTnI results on the ACCESS analyzer. Repeat centrifugation eliminates false-positive results. The presence of thrombin in collection tubes does not significantly affect cTnI results by this assay. Roberts et al. (3 ) published similar results.

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عنوان ژورنال:
  • Clinical chemistry

دوره 46 11  شماره 

صفحات  -

تاریخ انتشار 2000